Hi, I used wisecare some time back, and as per leo notes, aggressive cleaning also eats some system files which is listed in those cleaners. Even care should be taken when cleaning registry with ccleaner. I used to clean the three cleaners, but now i leave the registry and carefully studying before cleaning.
I also would download adware cleaner for malware bytes, that it is having huge user interface, but leaving browser hijacks as it is , as Shane has pointed out.
Regarding Boggins suggestion of JRT, I first advised everybody and also used the same to clean not deletable root kits. But the drawback is that user has no say in it. It is doing its job silently and user has no control whether to delete a file or not. It washed them all. But so far, it is good in cleaning adware and suspicious files inside registries also.
Boggins, where is the adw cleaner link to see what JRT cleans