Are you able to boot up into the advanced boot options to select Safe Mode with Command Prompt or Safe Mode with Networking ?
If you can get with Networking, download and run ESET Free Online Scanner.
http://www.eset.com/us/online-scanner/Check the two boxes for PuPs and PuMs then click on Advanced and check all of the boxes excluding Proxy and the Archives one is optional.
See what that reports then run this ESET Services Repair Tool.
http://kb.eset.com/library/ESET/KB%20Team%20Only/Malware/ServicesRepair.exe (active link)
You may be able to run Windows Repair to reset the Permissions in Safe Mode with Networking.
If you can't and you can boot up into the advanced boot options, select Safe Mode with Command Prompt and enter -
net user administrator /active:yes
shutdown /r /t 00
After the reboot you should see the admin icon to log in with and then see if WR will run.
That cmd invokes the hidden admin account and to disable it when done, change active:yes to active:no