As well as running Combofix, you can also still run ESET Online Scanner in Safe Mode with Networking and while either of these programs will pick up Trojans/Viruses etc. they may not see PuPs as malware.
I've seen both MBAM and SuperAntiSpyware report that they have found and removed PuPs just for them to return.
You could try JRT in Safe Mode to see if it fares any better, but I've found a safe download site for AdwCleaner which is specifically designed for dealing with PuPs and is probably also best downloading and running in Safe Mode with Networking
https://toolslib.net/downloads/viewdownload/1-adwcleaner/This program doesn't install on your computer unless you select Save and then run its .exe Application from wherever you have your computer set to save downloads.
With this program, click on Clean and it may list items in the Results window below - if there is anything in there that you want to keep, then uncheck those boxes - otherwise when the Scan has completed, click on Report and it will show you what it has found.
Close the Report then click on Clean, follow the prompts and it will produce another report of what it has cleaned after the reboot.