My user reported to me that she was having variable results on searching (this is on Windows 10 x64), so I ran the troubleshooter and it claimed that the search repository directories had incorrect permissions. I tried to fix it manually, but that wouldn't make the error go away. So I ran the latest tweaking.com.
Upon logging in after the repair, I got this screen
As you can see, all the text has been eliminated and windows don't always open to their full size and that includes menus. Indeed, with the exception of the search box, pretty much nothing works. This is true in safe mode.
I was able to run chkdsk, which found no errors. I cannot run sfc /scannow without its complaining of a Windows Resource Protection error. I had to run these checks while the disk was plugged in externally since obviously nothing can be done from within its own Windows.